Hi All, this is my first post in hopefully a long line of posts. I was diagnosed with Iga Kappa MGUS 4 years ago but 4 weeks ago found out that I now have high risk Smouldering Myeloma. With an abnormal Kappa/Lambda ratio and 15% plasma cell load (plus Iga papaprotein which has a higher risk of progression than other types of Myeloma) I am debating as to whether I should enter into early treatment. I live in Australia and at present first line treatment is still " watch and wait" until some signs of end organ damage is present. I am wondering if anyone has gone down the early treatment course and what the results of this where.
Cheers, Leigh
Hi Leigh,
ReplyDeleteI was wondering what is the number of your kappa/lamda ratio? At UAMS-MIRT in Little Rock ARK. they measure it more finely with a g/dl ratio.
I too am smoldering and awaiting the Natural Killer cell trial??? if I qualify, hopefully at the above institution. Sounds like from your figures you might qualify. It is a long journey from down under to Little Rock but it might be worth checking out.
Good Luck
I stand corrected the measure is MG/DL not grams/dl
ReplyDeleteI recommend if you have not already check out International Myeloma Foundation they have many publications on MM.
Hi Keith, my kappa/Lambda ratio is 7.9. Kappa 38mg/L Lambda 5mg/l (Done by FLC assay). Plasma cell load is 15% and Iga spike is 12g/l. I am heading back for my 8 weekly blood tests next week and they are also now testing for LDH so will be interesting to see the results of that. At present I have not had any other symptoms although I am starting to get some dull aches in my kidneys and very frothy urine from the extra protein. In Australia you normally have had to have 2 rounds of treatment before you qualify for any clinical trials but I have already offered my services to the relevant groups.
ReplyDeletecheers
Leigh